Anything is possible, just depends on how much money you want to throw at it and what you want to achieve.
In the past I have pushed a Manta engine into a Chevette with little work. After that expired I then dropped a Rover V8 in it, but that required a bit of engineering, but boy was it quick when finished
I wouldn't mind a rwd conversion on the ZS for a track car, would make it a better balanced car on the loose. That's why Revivals have converted their ZS180 to rwd.